研究组名称：生态毒理学研究组 （英文）
   研究组英文名称： Ecotoxicology Research Group
   研究组长：戴家银 研究员

　研究队伍：
　　戴家银　研究员
　　许木启　研究员
　　曹　宏　高级实验师
　　王建设　助理研究员
　　张红霞 助理研究员
　　博士研究生：方雪梅，丰一兴，胡佳玥
　　硕士研究生：王富欣，张亚婷，刘宏，李妍

   研究方向：
       持久性有机污染物的环境行为、生态毒理效应和毒理作用机制研究。
       主要研究以典型全氟类化合物为代表的持久性有机污染物在环境介质中的分布和它们的环境过程；在分子、细胞、种群和群落水平上研究生物对污染胁迫的响应及其反馈。从生态毒理基因组学和蛋白质组学角度分析生物在环境污染物胁迫下其基因表达与调控的变化；寻找潜在的敏感、有效的暴露标记物，揭示污染物的毒作用机制。研究内陆水体水域生态系统结构与功能特征，水体污染的生态效应、原生动物群落的生物监测、受损害水域生态系统结构与功能重建与恢复的理论与方法。寻求有效的环境有毒有害污染物治理方法，为生态修复和生物的生境保护提供理论支撑和技术支持。

   代表性论文：（2006年以来发表的SCI论文 ）

1. Lina Ding, Fuhua Hao, Zhimin Shi, Yulan Wang, Hongxia Zhang, Huiru Tang, and Jiayin Dai*. (2009) Systemic responses to chronic perfluorododecanoic acid exposure studied by integrated metabonomics and transcriptomics. Journal of Proteome Research, 9, 2882-2991.
2. Xuemei Fang, Yixing Feng, Zhimin Shi and Jiayin Dai*. (2009) Alterations of Cytokines and MAPK Signaling Pathways Are Related to the Immunotoxic Effect of Perfluorononanoic Acid. Toxicological Sciences, 108, 367-376.
3. Zhimin Shi, Lina Ding, Hongxia Zhang, Yixing Feng, Muqi Xu, Jiayin Dai*. (2009) Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and related genes expressions in male rat. Toxicology Letters, 188, 192-200.
4. Zhimin Shi, Hongxia Zhang, Lina Ding, Yixing Feng, Muqi Xu, Jiayin Dai*. (2009) The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats. Reproductive Toxicology, 27, 352-359.
5. Yang Liu, Jianshe Wang, Yong Liu, Hongxia Zhang, Muqi Xu Jiayin Dai*. (2009) Expression of a novel cytochrome P450 4T gene in rare minnow (Gobiocypris rarus) following perfluorooctanoic acid exposure. Comparative Biochemistry and Physiology, Part C, 150, 57-64.
6. Yixing Feng, Zhimin Shi, Xuemei Fang, Muqi Xu, Jiayin Dai*. (2009) Perfluorononanoic Acid Induces Apoptosis Involving the Fas Death Receptor Signaling Pathway in Rat Testis. Toxicology Letters, DOI: 10.1016/j.toxlet.2009.07.020.
7. Yanhong Wei, Leo. L. Chan, Dazhi Wang, Hongxia Zhang, Jianshe Wang, Jiayin Dai*. (2008) Proteomic Analysis of Hepatic Protein Profiles in Rare Minnow (Gobiocypris rarus) Exposed to Perfluorooctanoic Acid. Journal of Proteome Research, 7, 1729-1739.
8. Guocheng Hu, Xiaojun Luo, Jiayin Dai*, Xiulan Zhang, Hua Wu, Chenglin Zhang, Wei Guo, Muqi Xu, Bixian Mai, Fuwen Wei.(2008) Brominated Flame Retardants, Polychlorinated Biphenyls, and Organochlorine Pesticides in Giant Panda (Ailuropoda melanoleuca) and Red Panda (Ailurus fulgens) from China. Environmental Science & Technology, 42, 4697-4703.
9. Xuemei Li, Leo W.Y. Yeung, Sachi Taniyasu, Ming Li, Hongxia Zhang, Dan Liu, Paul K.S. Lam, and Jiayin Dai*. (2008) Perfluorooctanesulfonate and Related Fluorochemicals in the Amur Tiger (Panthera tigris altaica) from China. Environmental Science & Technology, 42, 7078-7083.
10. Guocheng Hu, Jiayin Dai*, Muqi Xu, Xiaojun Luo, and Bixian Mai. (2008) Response to Comment on “Brominated Flame Retardants, Polychlorinated Biphenyls, and Organochlorine Pesticides in Captive Giant Panda (Ailuropoda melanoleuca) and Red Panda (Ailurus fulgens) from China. Environmental Science & Technology, 42, 8173-8174.
11. Yanhong Wei, Yang Liu, Jianshe Wang, Yi Tao, Jiayin Dai*. (2008) Toxicogenomic Analysis of the Hepatic Effects of Perfluorooctanoic Acid on Male and Female Rare Minnows(Gobiocypris rarus). Toxicology and Applied Pharmacology, 226, 285-297.
12. Hongxia Zhang, Zhimin Shi, Yang Liu, Yanhong Wei, Jiayin Dai*. (2008) Response of Lipid Homeostasis and Oxidative Stress in the Liver of Male Rats Exposed to Perfluorododecanoic acid. Toxicology and Applied Pharmacology, 227, 16-25.
13. Xuemei Fang, Lianjun Zhang, Yixing Feng, Yong Zhao, Jiayin Dai*. (2008) Immunotoxic Effects of Perfluorononanoic Acid on BALB/c Mice. Toxicological Sciences, 105, 312-21.
14. Xuemei Li, Leo Wai Yin Yeung, Muqi Xu, Sachi Taniyasu, Paul K.S. Lam, Nobuyoshi Yamashita, Jiayin Dai*. (2008). Perfluorooctane sulfonate (PFOS) and other fluorochemicals in zooplankton and fish collected near the outfall of wastewater treatment plant (WWTP) in Beijing. Environmental Pollution, 156, 1298-1303.
15. Yong Liu, Jianshe Wang, Yanhong Wei, Hongxia Zhang, and Jiayin Dai*. (2008) Molecular characterization of cytochrome P450 3A and 1A and the effects of perfluorooctanoic acid on their expression in rare minnow (Gobiocypris rarus) gills. Aquatic toxicology, 88, 183-190.
16. Yang Liu, Jianshe Wang, Yanhong Wei, Hongxia Zhang, Muqi Xu, and Jiayin Dai*. (2008) Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquatic toxicology, 89, 242-250.
17. Xuemei Li, Leo Wai Yin Yeung, Sachi Taniyasu, Paul K. S. Lam, Nobuyoshi Yamashita, Muqi Xu, Jiayin Dai*. (2008) Perfluorinated compounds in Bengal tiger (Panthera tigris tigris) and African lion (Panthera leo Linnaeus) in China. Chemosphere, 73, 1649-1653.
18. Jianshe Wang, Yanhong Wei, Dazhi Wang, Leo. L. Chan, and Jiayin Dai*. (2008) Proteomic study of the effects of complex environmental stresses in the livers of goldfish (Carassius auratus) that inhabit Gaobeidian Lake in Beijing, China. Ecotoxicology, 17, 213-220.
19. Jianshe Wang, Zhiyong Feng, Dandan Yao, Jingjing Sui, Wenqing Zhong, Jiayin Dai*. (2008) Warfarin Resistance in Rattus losea in Guangdong Province, China. Pesticide Biochemistry and Physiology, 91, 90-95.
20. Lingling Deng, Muqi Xu, Hong Cao, and Jiayin Dai*. (2008) Ecotoxicological effects of buprofezin on fecundity, growth, development and predation of the wolf spider, PIRATA PIRATOIDES (Schenkel), Archives of Environmental Contamination and Toxicology, 55, 652-658.
21. Xuemei Li, Yiping Gan, Xiangping Yang, Jun Zhou, Jiayin Dai, Muqi Xu. (2008) Human health risk of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in edible fish from Huairou Reservoir and Gaobeidian Lake in Beijing, China. Food Chemistry, 109, 348-354.
22. Xuemei Li, Qinghua Zhang, Jiayin Dai, Yiping Gan, Jun Zhou, Xiangping Yang, Hong Cao, Guibin Jiang, Muqi Xu. (2008) Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeidian Wastewater Treatment Plant. Chemosphere, 72, 1145-1151.
23. Jun Xu, Min Yang，Jiayin Dai, Hong Cao , Canping Pan, Xinghui Qiu, Muqi Xu. (2008) Degradation of acetochlor by four microbial communities, Bioresource Technology, 99, 7797-7802.
24. Jiayin Dai*, Muqi Xu, Jiping Chen, Xiangping Yang, Zhenshan Ke. (2007) PCDD/F, PAH and heavy metals in the sewage sludge from six wastewater treatment plants in Beijing, China. Chemosphere, 66, 353-361.
25. Zhimin Shi, Hongxia Zhang, Yang Liu, Muqi Xu, Jiayin Dai*. (2007) Alterations in Gene Expression and Testosterone Synthesis in the Testes of Male Rats Exposed to Perfluorododecanoic Acid. Toxicological Sciences, 98, 206-215.
26. Jianshe Wang, Yanhong Wei, Xuemei Li, Hong Cao, Muqi Xu, Jiayin Dai*. (2007) The identification of heat shock protein genes in goldfish (Carassius auratus) and their expression in a complex environment in Gaobeidian Lake, Beijing, China. Comparative Biochemistry and Physiology, Part C, 145, 350-362.
27. Lingling Deng, Jiayin Dai Hong Cao, and Muqi Xu. (2007) Effects of methamidophos on the pest control potential of Hylyphantes graminicola (Sundevall) (Araneae: Linyphiidae). Environmental Toxicology and Chemistry, 26, 478-482.
28. Jianshe Wang, Yanhong Wei, Xuemei Li, Muqi Xu, Jiayin Dai*. (2007) Identification of differentially expressed genes from contaminant and thermal exposed goldfish Carassius auratus in Gaobeidian Lake in Beijing, China. Ecotoxicology, 16, 525-532.
29. Yanhong Wei, Jiayin Dai*, Min Liu, Jianshe Wang, Muqi Xu, Jinmiao Zha, Zijian Wang. (2007) Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus). Environmental Toxicology and Chemistry, 26, 2440-2447.
30. Yanhong Wei, Jianshe Wang, Xiaowei Zhang, Muqi Xu, Jiayin Dai*. (2007) Identification and characterization of expressed sequence tags from the liver of rare minnow (Gobiocypris rarus). Comparative Biochemistry and Physiology, Part D, 2, 356-362.
31. Yi-Jun Wu, Ming Li, Yu-Xia Li, Wei Li, Jiayin Dai and Xin-Fu Leng. (2007) Verapamil abolished the enhancement of protein phosphorylation of brainstem mitochondria and synaptosomes from the hens dosed with tri-o-cresyl phosphate. Environmental Toxicology and Pharmacology, 24, 67-71.
32. Jiayin Dai*, Ming Li, Yihe Jin, Norimitsu Saito, Muqi Xu, Fuwen Wei. (2006) Perfluorooctanesulfonate and Perfluorooctanoate in Red Panda and Giant Panda from China. Environmental Science & Technology, 40, 5647-5652.
33. Lingling Deng, Jiayin Dai* Hong Cao, and Muqi Xu. (2006) Effects of organophosphorous insecticide on survival, fecundity and development of Hylyphantes graminicola (Sundevall) (Araneae: Linyphiidae). Environmental Toxicology and Chemistry, 25, 3073-3077.
34. Jiayin Dai, Ling Chen, Jianfu Zhao, Na Ma. (2006) Characteristics of Sewage Sludgeand Distribution of Heavy Metal in Plants with Amendment of Sewage Sludge. Journal of Environmental Science, 18, 1094-1100.
35. Jun Xu, Xinghui Qiu, Jiayin Dai, Hong Cao, Min Yang, Jing Zhang & Muqi Xu. (2006) Isolation and characterization of a Pseudomonas oleovorans degrading the chloroacetamide herbicide acetochlor. Biodegradation, 17, 219-225.
36. Kexin Zhou, Muqi Xu, Jiayin Dai, Hong Cao. (2006) The microfauna communities and operational monitoring of an activated sludge plant in China. European Journal of Protistology, 42, 291-295.